Jaime Hernandez was born in 1959 in Oxnard, California, where he grew up with his sister and four brothers in a family of Mexican immigrants.

His interest in comics was instilled by his mother's love of reading, who introduced him to the work of now-classic authors such as Jack Kirby and Steve Ditko, as well as the Archie and Peanuts comic strips. Mad Magazine opened his eyes to satire, but the real internal revolution came when one of his brothers brought home a copy of Zap Comix, Robert Crumb's mythical magazine.

To this attraction to underground comics was added the emergence of the punk rock scene in Los Angeles at the end of the seventies, which would impregnate Jaime's scripts and drawings with anarchic ideals and popular references, all incorporated into a microcosm of realistic and defined characters beyond any cliché.

In 1981, together with his brothers Beto and Mario, he founded the magazine Love & Rockets, an amateur medium to publish his comics. These comics were included in the prestigious Fantagraphics catalogue next year, which over time has become one of the great corps of American literary fiction. Since then, Jaime has continued to develop the Locas universe, winning numerous awards around the world, and since 2017 has been part of the prestigious Will Eisner Awards Hall of Fame.

Ediciones La Cúpula is preparing a definitive edition of Locas to be published in 2025, as well as the volume Dibujo del natural (Drawing from Life), which belongs to the same universe